1. Laparoscopic access
Two small incisions (5-12mm) are made to introduce the camera and nebulizer device into the abdominal cavity.
Innovative Procedure
PIPAC: Pressurized Intraperitoneal Aerosol Chemotherapy
Minimally invasive technique that delivers chemotherapy as a pressurized aerosol directly into the abdominal cavity for the treatment of peritoneal carcinomatosis.
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What is PIPAC?
PIPAC (Pressurized Intraperitoneal Aerosol Chemotherapy) is an innovative technique that delivers chemotherapy as a pressurized aerosol directly into the abdominal cavity. It is performed via laparoscopy, making it a minimally invasive procedure.
Unlike HIPEC, PIPAC can be performed repeatedly and is especially indicated for patients with extensive peritoneal carcinomatosis who are not candidates for complete cytoreductive surgery, or as neoadjuvant treatment to reduce tumor burden.
How is the PIPAC procedure performed?
PIPAC is performed in the operating room under general anesthesia using laparoscopic technique:
2. Exploration and biopsy
Visual evaluation of the abdominal cavity, documentation of tumor extent, and biopsies for histological analysis.
3. Drug nebulization
Chemotherapy is nebulized at high pressure (12 mmHg) creating an aerosol that distributes evenly across the entire peritoneal surface.
4. Exposure time
The aerosol remains in contact with the peritoneum for 30 minutes, after which it is safely evacuated and the incisions are closed.
Advantages of PIPAC
PIPAC offers multiple advantages over other peritoneal carcinomatosis treatments:
Minimally invasive
Performed laparoscopically through only two small incisions, allowing rapid patient recovery.
Repeatable
Can be performed multiple times (every 6-8 weeks), allowing sustained treatment of peritoneal disease.
Greater penetration
The aerosol pressure allows chemotherapy to penetrate deeper into tumor tissue than liquid chemotherapy.
Good tolerance
Systemic toxicity is very low, allowing patients to maintain quality of life during treatment.
PIPAC indications
PIPAC is especially indicated in the following situations:
Unresectable carcinomatosis
Patients with extensive peritoneal carcinomatosis who are not candidates for complete cytoreductive surgery with HIPEC.
Neoadjuvant treatment
To reduce tumor burden before definitive cytoreductive surgery, converting inoperable cases to operable ones.
Peritoneal recurrence
In patients with carcinomatosis recurrence after previous treatment with HIPEC or other therapies.
Palliative control
To control malignant ascites and improve quality of life in patients with advanced disease.
Our experience in PIPAC
At Quenet-Torrent Institute we were pioneers in introducing PIPAC in Spain and have one of the largest series of patients treated with this technique. Our team has developed specific treatment protocols and actively participates in international clinical trials.
The PIPAC technique complements our therapeutic offering for peritoneal carcinomatosis, providing treatment alternatives to patients who previously had no surgical options.
Pathologies treated with PIPAC
The PIPAC procedure is used in the treatment of various pathologies with peritoneal involvement.
Peritoneal carcinomatosis
Treatment of peritoneal tumor spread from various origins.
More informationGynecological tumors
Especially useful in advanced or recurrent ovarian cancer.
More informationEsophagogastric tumors
In unresectable gastric carcinomatosis.
More information
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